MURAGAKI Yoshihiro    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Visiting Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Differential Effects of a Left Frontal Glioma on the Cortical Thickness and Complexity of Both Hemispheres.
Journal	Formal name：Cerebral cortex communications Abbreviation：Cereb Cortex Commun ISSN code：26327376/26327376
Domestic / Foregin	Foregin
Volume, Issue, Page	1(1),pp.tgaa027
Author and coauthor	KINNO Ryuta†, MURAGAKI Yoshihiro, MARUYAMA Takashi, TAMURA Manabu, TANAKA Kyohei, ONO Kenjiro, SAKAI Kuniyoshi L*
Authorship	2nd author
Publication date	2020/07/24
Summary	Glioma is a type of brain tumor that infiltrates and compresses the brain as it grows. Focal gliomas affect functional connectivity both in the local region of the lesion and the global network of the brain. Any anatomical changes associated with a glioma should thus be clarified. We examined the cortical structures of 15 patients with a glioma in the left lateral frontal cortex and compared them with those of 15 healthy controls by surface-based morphometry. Two regional parameters were measured with 3D-MRI: the cortical thickness (CT) and cortical fractal dimension (FD). The FD serves as an index of the topological complexity of a local cortical surface. Our comparative analyses of these parameters revealed that the left frontal gliomas had global effects on the cortical structures of both hemispheres. The structural changes in the right hemisphere were mainly characterized by a decrease in CT and mild concomitant decrease in FD, whereas those in the peripheral regions of the glioma (left hemisphere) were mainly characterized by a decrease in FD with relative preservation of CT. These differences were found irrespective of tumor volume, location, or grade. These results elucidate the structural effects of gliomas, which extend to the distant contralateral regions.
DOI	10.1093/texcom/tgaa027
PMID	34296101