ムラガキ ヨシヒロ   MURAGAKI Yoshihiro
  村垣 善浩
   所属   研究施設 研究施設
   職種   教授
論文種別 症例報告
言語種別 英語
査読の有無 査読あり
表題 Epidermal growth factor receptor (EGFR) amplification rates observed in screening patients for randomized trials in glioblastoma
掲載誌名 正式名:Journal of Neuro-Oncology
ISSNコード:0167594X
掲載区分国外
巻・号・頁 144(1),205-210頁
著者・共著者 LASSMAN Andrew B†., ALDAPE Kenneth D. , ANSELL Peter J. , BAIN Earle , CURRAN Walter J., EOIL Marica , FRENCH Pim J. , KINOSHITA Manabu , LOOMAN Jim , MRHTA Minesh, MURAGAKI Yoshihiro, NARITA Yoshitaka, OCAMPO Christopher , LISA Roberts-Rapp, SONG Minghao , VOGELBAUM Michael A., WALENKAMP Annemiek M. E., WANG Tony J. C. , ZHANG Peixin, van den BENT Martin J.
発行年月 2019/08
概要 Purpose
Epidermal growth factor receptor (EGFR) amplification has been reported to occur in ~ 50% of glioblastomas (GBMs). We are conducting several global studies that require central testing for EGFR amplification during screening, representing an opportunity to confirm the frequency of amplification in GBM in a large cohort and to evaluate whether EGFR amplification differs by region of the world.

Methods
EGFR amplification was measured by fluorescence in situ hybridization during screening for therapeutic trials of an EGFR antibody–drug conjugate: two Phase 2/3 global trials (INTELLANCE-1, INTELLANCE-2), and a Japanese Phase 1/2 trial (INTELLANCE-J). We evaluated the proportion of tumor tissue samples harboring EGFR amplification among those tested and differences in amplification frequency by geography.

Results
EGFR was amplified in 54% of 3150 informative cases screened for INTELLANCE-1 and -2, consistent with historic controls, but was significantly lower in patients from Asia versus the rest of the world (35% vs. 56%, P < 0.0030). The independent INTELLANCE-J trial validated this finding (33% amplified of 153 informative cases).

Conclusions
EGFR amplification occurs less frequently in patients from Asia than elsewhere. Further study is required to understand biological differences to optimize treatment in glioblastoma.
DOI 10.1007/s11060-019-03222-y
PMID 31273577