|
MURAGAKI Yoshihiro
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Visiting Professor |
|
| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Sonodynamic Therapy with Anticancer Micelles and High-Intensity Focused Ultrasound in Treatment of Canine Cancer |
| Journal | Formal name：Frontiers in Pharmacology ISSN code：16639812 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 10,pp.545 |
| Author and coauthor | HORISE Yuki†, MAEDA Masanori, KONISHI Yoshiyuki, OKAMOTO Jun, IKUTA Soko, OKAMOTO yoshiharu , ISHII Hiroshi, YOSHIZAWA YOSHIZAWA,Shin, UMEMURA Shinichiro, UEYAMA Tsuyoshi , TAMANO Satoshi , SOFUNI Atsushi , TAKEMAE Kazuhisa , MASAMUNE Ken, ISEKI Hiroshi, NISHIYAMA Nobuhiro, KATAOKA Kazunori , MURAGAKI Yoshihiro |
| Authorship | Last author,Corresponding author |
| Publication date | 2019/05/21 |
| Summary | Sonodynamic therapy (SDT) is a minimally invasive anticancer therapy involving a chemical sonosensitizer and high-intensity focused ultrasound (HIFU). SDT enables the reduction of drug dose and HIFU irradiation power compared to those of conventional monotherapies. In our previous study, mouse models of colon and pancreatic cancer were used to confirm the effectiveness of SDT vs. drug-only or HIFU-only therapy. To validate its usefulness, we performed a clinical trial of SDT using an anticancer micelle (NC-6300) and our HIFU system in four pet dogs with spontaneous tumors, including chondrosarcoma, osteosarcoma, hepatocellular cancer, and prostate cancer. The fact that no adverse events were observed, suggests the usefulness of SDT. |
| DOI | 10.3389/fphar.2019.00545 |