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MURAGAKI Yoshihiro
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Visiting Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Elevated TERT Expression in TERT-Wildtype Adult Diffuse Gliomas: Histological Evaluation with a Novel TERT-Specific Antibody. |
| Journal | Formal name：BioMed research international. ISSN code：23146133/23146141 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 10,pp.1-12 |
| Author and coauthor | MASUI Kenta†, KOMORI Takashi, KATO, Yukinari, MASUTOMI,Kenkichi Kenkichi, ICHIMURA Koichi, OGASAWARA Satoshi, KANEKO Mika K, OKI Hiroharu, SUZUKI Hiroyoshi, NITTA Masayuki, MARUYAMA Takashi, MURAGAKI Yoshihiro, KAWAMATA Takakazu, SAWADA Tatsuo, SHIBATA Noriyuki |
| Publication date | 2018/03 |
| Summary | Telomerase reverse transcriptase (TERT) is important for the biology of diffuse gliomas. TERT promoter mutations are selectively observed among 1p/19q-codeleted oligodendrogliomas and isocitrate dehydrogenase gene- (IDH-) wildtype glioblastoma (GBM). However, TERT transcripts range widely in various cancers including gliomas, and TERT protein expression has been rarely investigated thus far. It would be thus critical to examine the expression level of TERT in tumors in addition to its mutational status, and sensitive and specific methods are urgently needed to examine TERT protein expression for the assessment of TERT biology in gliomas. Using our newly developed TERT-specific monoclonal antibody (TMab-6) applicable to human tissue, we found an unexpected increase in TERT expression in TERT-wildtype as well as TERT-mutated gliomas and in tumor vasculature. This is the first extensive analysis on the expression of TERT immunoreactivity in human glioma tissue, suggesting that TERT protein expression may be regulated by several mechanisms in addition to its promoter mutation. |
| DOI | 10.1155/2018/7945845 |
| PMID | 29693015 |