ムラガキ ヨシヒロ   MURAGAKI Yoshihiro
  村垣 善浩
   所属   研究施設 研究施設
   職種   教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Elevated TERT Expression in TERT-Wildtype Adult Diffuse Gliomas: Histological Evaluation with a Novel TERT-Specific Antibody.
掲載誌名 正式名:BioMed research international
略  称:Biomed Res Int
ISSNコード:23146141
掲載区分国外
巻・号・頁 10,1-12頁
著者・共著者 MASUI Kenta†, KOMORI Takashi, KATO, Yukinari, MASUTOMI,Kenkichi Kenkichi, ICHIMURA Koichi, OGASAWARA Satoshi, KANEKO Mika K, OKI Hiroharu, SUZUKI Hiroyoshi, NITTA Masayuki, MARUYAMA Takashi, MURAGAKI Yoshihiro, KAWAMATA Takakazu, SAWADA Tatsuo, SHIBATA Noriyuki
発行年月 2018/03
概要 Telomerase reverse transcriptase (TERT) is important for the biology of diffuse gliomas. TERT promoter mutations are selectively observed among 1p/19q-codeleted oligodendrogliomas and isocitrate dehydrogenase gene- (IDH-) wildtype glioblastoma (GBM). However, TERT transcripts range widely in various cancers including gliomas, and TERT protein expression has been rarely investigated thus far. It would be thus critical to examine the expression level of TERT in tumors in addition to its mutational status, and sensitive and specific methods are urgently needed to examine TERT protein expression for the assessment of TERT biology in gliomas. Using our newly developed TERT-specific monoclonal antibody (TMab-6) applicable to human tissue, we found an unexpected increase in TERT expression in TERT-wildtype as well as TERT-mutated gliomas and in tumor vasculature. This is the first extensive analysis on the expression of TERT immunoreactivity in human glioma tissue, suggesting that TERT protein expression may be regulated by several mechanisms in addition to its promoter mutation.
DOI 10.1155/2018/7945845
PMID 29693015