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MURAGAKI Yoshihiro
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Visiting Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Prognostic implications of the subcellular localization of survivin in glioblastomas treated with radiotherapy plus concomitant and adjuvant temozolomide |
| Journal | Formal name：Journal of neurosurgery Abbreviation：J Neurosurg ISSN code：00223085 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 128(3),pp.679-684 |
| Author and coauthor | SAITO Taiichi†, SUGIYAMA,Kazuhiko Kazuhiko, TAKESHIMA,Yukio Yukio , AMATYA Vishwa Jeet, YAMASAKI Fumiyuki , TAKAYASU Takeshi , NOSAKA Ryo , MURAGAKI Yoshihiro, KAWAMATA Takakazu, KURISU Kaoru |
| Publication date | 2018/03 |
| Summary | OBJECTIVECurrently, the standard treatment protocol for patients with newly diagnosed glioblastoma (GBM) includes surgery, radiotherapy, and concomitant and adjuvant temozolomide (TMZ). Various prognostic biomarkers for GBM have been described, including survivin expression. The aim of this study was to determine whether the subcellular localization of survivin correlates with GBM prognosis in patients who received the standard treatment protocol.METHODSThe authors retrospectively examined the subcellular localization of survivin (nuclear, cytoplasmic, or both) using immunohistochemistry in 50 patients with GBM who had received the standard treatment. The relationship between survivin localization and overall survival (OS) was assessed with uni- and multivariate analyses including other clinicopathological factors (age, sex, Karnofsky Performance Scale [KPS]score, extent of resection, the use of second-line bevacizumab, O6-methylguanine-DNA methyltransferase [MGMT]status, and MIB-1 labeling index).RESULTSLog-rank tests revealed that patient age, KPS score, extent of resection, MGMT status, and survivin localization (p<0.0001) significantly correlated with OS. Multivariate analysis indicated that patient age, MGMT status, and survivin localization significantly correlated with OS.Patients with nuclear localization of survivin had a significantly shorter OS than those in whom survivin expression was exclusively cytoplasmic (median OS 19.5 vs 31.7 months, respectively, HR 5.690, 95% CI 2.068 |
| DOI | 10.3171/2016.11.JNS162326. |
| PMID | 28430038 |