MURAGAKI Yoshihiro    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Visiting Professor
Article types	Other
Language	English
Peer review	Peer reviewed
Title	Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery
Journal	Formal name：Med Image Comput Comput Assist Interv
Domestic / Foregin	Foregin
Publisher	Springer, Berlin, Heidelberg
Volume, Issue, Page	11(Pt 2),pp.373-380
Author and coauthor	LIAO Hongen†, SHIMAYA Koji , WANG Kaimeng , NOGUCHI Masafumi , MURAGAKI Yoshihiro, KOBAYASHI Etsuko , ISEKI Hiroshi, SAKUMA Ichiro
Publication date	2008/09
Summary	A combination of 5-aminolevulinic acid (5-ALA)-induced fluorescence and three-dimensional (3-D) magnetic resonance imaging (MRI) of a brain tumor has been incorporated into a robotic laser ablation neurosurgery system. 5-ALA is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent protoporphyrins IX (PpIX) in malignant glioma. The PpIX tends to accumulate in pathological lesions, and emits red fluorescence when excited by blue light. This fluorescence is illuminated with laser excitation, enables intra-operative identification of the position of a tumor and provides guidance for resection with laser photocoagulation. The information provided by the MRI is enhanced by the 5-ALA fluorescence data, and this enhanced information is integrated into a robotic laser ablation system. The accuracy of the fluorescent measurement of the tumor is improved using high-precision spectral analysis. The fluorescence assists in the detection of malignant brain tumors intraoperatively and improves their removal rate.
DOI	doi.org/10.1007/978-3-540-85990-1_45
Document No.	18982627