ムラガキ ヨシヒロ   MURAGAKI Yoshihiro
  村垣 善浩
   所属   研究施設 研究施設
   職種   教授
論文種別 その他
言語種別 英語
査読の有無 査読あり
表題 Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery
掲載誌名 正式名:Med Image Comput Comput Assist Interv
掲載区分国外
出版社 Springer, Berlin, Heidelberg
巻・号・頁 11(Pt 2),373-380頁
著者・共著者 LIAO Hongen†, SHIMAYA Koji , WANG Kaimeng , NOGUCHI Masafumi , MURAGAKI Yoshihiro, KOBAYASHI Etsuko , ISEKI Hiroshi, SAKUMA Ichiro
発行年月 2008/09
概要 A combination of 5-aminolevulinic acid (5-ALA)-induced fluorescence and three-dimensional (3-D) magnetic resonance imaging (MRI) of a brain tumor has been incorporated into a robotic laser ablation neurosurgery system. 5-ALA is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent protoporphyrins IX (PpIX) in malignant glioma. The PpIX tends to accumulate in pathological lesions, and emits red fluorescence when excited by blue light. This fluorescence is illuminated with laser excitation, enables intra-operative identification of the position of a tumor and provides guidance for resection with laser photocoagulation. The information provided by the MRI is enhanced by the 5-ALA fluorescence data, and this enhanced information is integrated into a robotic laser ablation system. The accuracy of the fluorescent measurement of the tumor is improved using high-precision spectral analysis. The fluorescence assists in the detection of malignant brain tumors intraoperatively and improves their removal rate.
DOI doi.org/10.1007/978-3-540-85990-1_45
文献番号 18982627