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MURAGAKI Yoshihiro
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Visiting Professor |
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| Article types | Case report |
| Language | English |
| Peer review | Peer reviewed |
| Title | Functional plasticity of Language Confirmed with Intraoperative Electrical Stimulations and Updated Neuronavigation: Case report of Loe-Grade Glioma of the Left Inferior Frontal Gyrus |
| Journal | Formal name：Neurologia medico-chirurgica Abbreviation：Neurol Med Chir (Tokyo) ISSN code：1349-8029 (Electronic)0470-8105 (Linking) |
| Volume, Issue, Page | 54(7),pp.587-592 |
| Author and coauthor | SAITO Taiichi†, MURAGAKI Yoshihiro, MIURA Isamu, TAMURA Manabu, MARUYAMA Takashi, NITTA Masayuki, KURIS Kaoru, ISEKI Hiroshi, OKADA Yoshikazu |
| Publication date | 2014/07 |
| Summary | Removal of glioma from the dominant side of the inferior frontal gyrus (IFG) is associated with a risk of permanent language dysfunction. While intraoperative cortical and subcortical electrical stimulations can be used for functional language mapping in an effort to reduce the risk of postoperative neurological impairment, the extent of resection is limited by the functional boundaries. Recent reports proposed that a two-stage surgical approach for low-grade glioma in eloquent areas could avoid permanent deficits via the functional plasticity that occurs between the two operations. The report describes a patient with World Health Organization (WHO) grade II oligoastrocytoma in the left IFG, in functional plasticity of language occurred in the interval between two consecutive surgeries. Intraoperative electrical stimulations suggested that a language area and related subcortical fiber crossed the pre-central sulcus during tumor progression owing to functional plasticity. In the present case, we integrated neurophysiological data into the intraoperative neuronavigation system. We also confirmed the peri-lesional shift of language area and related subcortical fiber on image findings. Consequently, the tumor was sub-totally removed with two separate resections. Permanent language disturbance did not occur, and this favorable outcome was attributed to functional plasticity. The present experience sustains the multistage approach for low-grade gliomas in the language area. A combination of intraoperative electrical stimulations and updated neuronavigation may facilitate the characterization of brain functional plasticity. |
| DOI | 10.2176/nmc.cr.2013-0248 |
| Document No. | PMCID: PMC4533461 |