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MURAGAKI Yoshihiro
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Visiting Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Cortical responses to C-fiber stimulation by intra-epidermal electrical stimulation: An MEG study. |
| Journal | Formal name：Neuroscience letters Abbreviation：Neurosci Lett ISSN code：03043940 |
| Volume, Issue, Page | (570),pp.69-74 |
| Author and coauthor | MOTOGI Jun†, KODAIRA Minori, MURAGAKI Yoshihiro, INUI Koji, KAKIGI Ryusuke |
| Publication date | 2014/06 |
| Summary | Intra-epidermal electric stimulation (IES) is an alternative to laser stimulation for selective activation of cutaneous Adelta-fibers. IES is based on the fact that nociceptive fiber terminals are located in the epidermis, whereas receptors of other fibers end deep in the dermis. IES can selectively stimulate C-fibers if the electrode structure and stimulation parameters are carefully selected. However, stable selective stimulation of C-fibers using IES has proven difficult and cannot currently be used in clinical settings. The purpose of the present study was to determine if IES performed using a modified electrode reliably stimulates C-fibers. Magnetoencephalographic responses to IES to the foot were measured in seven healthy subjects. IES elicited somatosensory evoked fields in all subjects. The mean peak latency was 1,327 +/- 116 ms in the opercular region contralateral to the stimulated side, 1,318 +/- 90 ms in the opercular region ipsilateral to the stimulated side, and 1350 +/- 139 ms in the primary somatosensory cortex. These results indicate that IES performed using the modified electrode can selectively stimulate C-fibers and may be a useful tool for pain research as well as clinical evaluation of peripheral small fiber function. |
| DOI | 10.1016/j.neulet.2014.04.001. |
| NAID | 500000994083 |
| PMID | 24731795 |