ムラガキ　ヨシヒロ   MURAGAKI Yoshihiro   村垣　善浩    所属   医学部 医学科（東京女子医科大学病院）    職種   客員教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Cortical responses to C-fiber stimulation by intra-epidermal electrical stimulation: An MEG study.
掲載誌名	正式名：Neuroscience letters 略　 称：Neurosci Lett ISSNコード：03043940
巻・号・頁	(570),pp.69-74
著者・共著者	MOTOGI Jun†, KODAIRA Minori, MURAGAKI Yoshihiro, INUI Koji, KAKIGI Ryusuke
発行年月	2014/06
概要	Intra-epidermal electric stimulation (IES) is an alternative to laser stimulation for selective activation of cutaneous Adelta-fibers. IES is based on the fact that nociceptive fiber terminals are located in the epidermis, whereas receptors of other fibers end deep in the dermis. IES can selectively stimulate C-fibers if the electrode structure and stimulation parameters are carefully selected. However, stable selective stimulation of C-fibers using IES has proven difficult and cannot currently be used in clinical settings. The purpose of the present study was to determine if IES performed using a modified electrode reliably stimulates C-fibers. Magnetoencephalographic responses to IES to the foot were measured in seven healthy subjects. IES elicited somatosensory evoked fields in all subjects. The mean peak latency was 1,327 +/- 116 ms in the opercular region contralateral to the stimulated side, 1,318 +/- 90 ms in the opercular region ipsilateral to the stimulated side, and 1350 +/- 139 ms in the primary somatosensory cortex. These results indicate that IES performed using the modified electrode can selectively stimulate C-fibers and may be a useful tool for pain research as well as clinical evaluation of peripheral small fiber function.
DOI	10.1016/j.neulet.2014.04.001.
NAID	500000994083
PMID	24731795