ムラガキ ヨシヒロ   MURAGAKI Yoshihiro
  村垣 善浩
   所属   研究施設 研究施設
   職種   教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 11C-Methionine Uptake Correlates with Combined 1p and 19q Loss of Heterozygosity in Oligodendroglial Tumors.
掲載誌名 正式名:AJNR. American journal of neuroradiology
略  称:AJNR Am J Neuroradiol
ISSNコード:1936959X(Electronic)01956108(Linking)
掲載区分国外
巻・号・頁 34(1),85-91頁
著者・共著者 SAITO Taichi†, MARUYAMA Takashi, MURAGAKI Yoshihiro, TANAKA Masahiko, NITTA Masayuki, SHINODA Jun, AKI Tatsuki, Iseki Hiroshi, KURISU Kaoru, OKADA Yoshikazu
発行年月 2013/01
概要 BACKGROUND AND PURPOSE:Oligodendroglial tumors with 1p/19q LOH are known to show longer patient survival than those without 1p/19q LOH, but the reason for this clinical difference has not been elucidated, to our knowledge. This study was designed to clarify whether uptake of MET correlates with 1p/19q LOH of oligodendroglial tumors.MATERIALS AND METHODS:This study included 102 consecutive patients with supratentorial WHO grade II and III oligodendroglial tumors (39 oligoastrocytic and 63 oligodendroglial tumors) that were resected and diagnosed between January 2008 and August 2011 at Tokyo Women's Medical University Hospital. These patients underwent MET PET T/N ratio measurement before treatment. T/N ratios were calculated by dividing the maximum SUV for the tumor by the mean SUV of the contralateral normal frontal cortex. After surgery, FISH for resected tissues was used to determine 1p/19q LOH.RESULTS:The mean T/N ratio of tumors with 1p/19q LOH was significantly greater than that of tumors without 1p/19q LOH (P = .0166). The threshold T/N ratio value of 2.46 was found to correlate significantly with 1p/19q LOH by univariate (P = .0011) and multivariate analyses (P = .0209) in all tumors.CONCLUSIONS:The T/N ratio on MET PET might be a useful aid to the diagnosis of 1p/19q LOH. Our data add new information on the biology and imaging characteristics of oligodendroglial tumors with 1p/19q LOH.
DOI 10.3174/ajnr.A3173
文献番号 22766670