MURAGAKI Yoshihiro    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Visiting Professor
Article types	Original article
Language	Japanese
Peer review	Peer reviewed
Title	Feasibility study of magnetic particle accumulation with a magnetic drug delivery system using a bulk high-temperature superconductive magnet
Volume, Issue, Page	pp.208-215
Publication date	2012/08
Summary	Magnetic drug delivery systems (MDDSs) using targeting magnetic responsive drugs and permanent magnets have been examined twice in clinical trials, but have yet to gain clinical use. One possible reason is a lack of availability of strong magnets. Accumulation of sufficient magnetic responsive drug into the tumor region is central to MDDS. Recent technical progress has realized a high magnetic field strength of 5.8 T and a steep magnetic field gradient of -480 T/m using bulk high-temperature superconductive (HTSC) magnets, compared with parameters of 0.6 T and -31 T/m using permanent magnets. The present study evaluated the accumulation performance of magnetic responsive drugs in an MDDS utilizing a bulk HTSC magnet. We adopted magnetic iron-oxide particles of 25, 80, 170 nm in diameter and magnetoliposomes as magnetic responsive drugs. The measured accumulation ranges to realize an accumulation rate >50% were 12, 48, 114, and 32 mm, respectively, 2.2 times longer than those measured using a permanent magnet. An in vivo experiment using swine liver was conducted to deliver iron-oxide particles of 100 nm in diameter. High accumulation of magnetic delivered drug was shown in T2*-weighted magnetic resonance imaging, under microscopic observation of stained histological sections, and with use of a superconducting quantum interference device (SQUID).
NAID	110009557326