MURAGAKI Yoshihiro    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Visiting Professor
Article types	Original article
Language	Japanese
Peer review	Peer reviewed
Title	Novel high-intensity focused ultrasound therapy using triggered pulse to reduce therapeutic time
Domestic / Foregin	Domestic
Volume, Issue, Page	pp.216-221
Publication date	2012/08
Summary	The use of high-intensity therapeutic ultrasound (HITU) for uterine fibroid is spreading, but problems remain, such as the small coagulation volume and long treatment time. Cavitation, representing the creation and implosion of microbubbles on application of a strong ultrasonic wave called a triggered pulse, offers a promising method to increase coagulation volume and optimize coagulation shape. We compared coagulation results in deep pectoral muscles in chicken under various conditions of heating wave power (36, 54 or 72 W) and pulse width and frequency of the triggered pulse (a: no triggered pulse; b: 30 μs and 1 kHz; c: 300 μs and 100 Hz; or d: 3 ms and 10 Hz). Coagulation shape in the target region, cavitation collapse ratio, and burn injuries on the skin surface were also evaluated. Coagulation volume increased significantly under all conditions of triggered pulse except condition b at 54 W. Oblateness was adopted as an index of coagulation shape, and decreased significantly toward a spherical shape under conditions c and d at 36 and 54 W, and condition d at 72 W. Coagulation results were optimized under condition d at 36 W and condition c at 54 W. Coagulation volume in the optimized condition increased 2 to 4 times compared with the control results (condition a), which allows a decrease in treatment time of 25-50% compared with current treatment protocols.
Document No.	2013081465
NAID	110009557327