ムラガキ ヨシヒロ   MURAGAKI Yoshihiro
  村垣 善浩
   所属   研究施設 研究施設
   職種   教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Coincidence of central neurocytoma and multiple glioblastomas:a rare cace report
掲載誌名 正式名:J Neurooncol
ISSNコード:1573-7373
巻・号・頁 93(3),431-435頁
著者・共著者 MURAGAKI Yoshihiro†, CHERNOV Mikhail, Tajika Yasuhiko Tajika Yasuhiko, KUBO Osami, ISEKI Hiroshi, HORI Tomokatsu
発行年月 2009/07
概要 Epub 2009 Jan 29.
Coincidence of parenchymal primary brain tumors of different histogenesis is extremely rare. To the best of our knowledge, the present case of simultaneous appearance of a central neurocytoma and multiple glioblastomas is the first to be reported. Multiple intraaxial brain neoplasms were disclosed in a 39-year-old man and were surgically resected. Histological diagnosis of the tumor located in the right lateral ventricle was central neurocytoma whereas two tumors of the left temporal lobe were glioblastomas. The latter were located in close proximity to the subarachnoid space, had atypical radiological appearance, and were slightly positive for synaptophysin and neurofilament protein. It can be speculated that both malignant neoplasms were, in fact, dedifferentiated central neurocytoma, which developed from distant tumor deposits. This case seems to be in agreement with the hypothesis that central neurocytoma arises from the progenitor cells with potential for both neuronal and glial differentiation. Better understanding of histogenesis of this tumor is definitely neede
DOI 10.1007/s11060-008-9793-0
PMID 19183852