シミズ　ユウコ   SHIMIZU Yuko   清水　優子    所属   医学部 医学科（東京女子医科大学病院）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Correlation of the symbol digit modalities test with the quality of life and depression in Japanese patients with multiple sclerosis
掲載誌名	正式名：Multiple sclerosis and related disorders 略　 称：Mult Scler Relat Disord ISSNコード：22110356/22110348
掲載区分	国外
巻・号・頁	57,pp.103427
著者・共著者	Niino Masaaki†*, Fukumoto Shoko, Okuno Tatsusada, Sanjo Nobuo, Fukaura Hikoaki, Mori Masahiro, Ohashi Takashi, Takeuchi Hideyuki, Shimizu Yuko, Fujimori Juichi, Kawachi Izumi, Kira Jun-Ichi, Takahashi Eri, Miyazaki Yusei, Mifune Nobuhiro
発行年月	2021/11
概要	BACKGROUND:This study aimed to evaluate the association between cognitive impairment and health-related quality of life (HRQOL), fatigue, and depression in Japanese patients with multiple sclerosis (MS).METHODS:The Brief International Cognitive Assessment for MS (BICAMS) was performed in 184 Japanese patients with MS. The Functional Assessment of MS (FAMS), Fatigue Severity Scale (FSS), and Beck Depression Inventory-Second Edition (BDI-II) were used to evaluate HRQOL, fatigue, and depression, respectively.RESULTS:Multiple linear regression analysis demonstrated positive correlations of the Symbol Digit Modalities Test (SDMT) with the scores on the FAMS subscales of mobility, symptoms, emotional well-being, and additional concerns and with the total FAMS score even after controlling for the Expanded Disability Status Scale score, age at examination, and duration of education. The SDMT score in the BICAMS battery had negative correlations with the BDI-II score, as revealed by multiple linear regression analysis. None of the three tests in the BICAMS had any correlation with the FSS score.CONCLUSION:The SDMT has a significant relationship with HRQOL and depression in Japanese patients with MS.
DOI	10.1016/j.msard.2021.103427
PMID	34861614