シミズ ユウコ   SHIMIZU Yuko
  清水 優子
   所属   医学部 医学科(東京女子医科大学病院)
   職種   准教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 The MG-QOL15 Japanese version: validation and associations with clinical factors.
掲載誌名 正式名:Muscle & nerve
略  称:Muscle Nerve
ISSNコード:10974598/0148639X
掲載区分国外
巻・号・頁 46(2),pp.166-173
著者・共著者 Masuda Masayuki, Utsugisawa Kimiaki, Suzuki Shigeaki, Nagane Yuriko, Kabasawa Chiaki, Suzuki Yasushi, Shimizu Yuko, Utsumi Hiroya, Fujihara Kazuo, Uchiyama Shinichiro, Suzuki Norihiro
発行年月 2012/08
概要 INTRODUCTION:Our study aim was to produce a Japanese translation of the 15-item Myasthenia Gravis Quality-of-Life Scale (MG-QOL15), assess its reliability and validity, and examine clinical factors affecting self-perceived QOL in MG.METHODS:We evaluated 327 consecutive patients with MG seen at six neurological centers. All patients completed the Japanese version of the MG-QOL15 (MG-QOL15-J), the Beck Depression Inventory-second edition (BDI-II), and a generic health-related QOL questionnaire, the SF-36. Disease severity was determined according to the Myasthenia Gravis Foundation of America (MGFA) quantitative MG score and the MG composite.RESULTS:The MG-QOL15-J exhibited adequate internal reliability, test-retest repeatability, and concurrent validity with SF-36, disease severity, and known-patient groups categorized by MGFA post-intervention status. Multivariate analysis revealed severity, dose of oral corticosteroids, and BDI-II as independent factors negatively affecting QOL.CONCLUSION:The MG-QOL15-J is anticipated to be a valuable clinical measure of QOL in Japanese patients with MG.
DOI 10.1002/mus.23398
PMID 22806364