シミズ　ユウコ   SHIMIZU Yuko   清水　優子    所属   医学部 医学科（東京女子医科大学病院）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Japanese cases of neuromyelitis optica spectrum disorder associated with myasthenia gravis and a review of the literature.
掲載誌名	正式名：Clinical neurology and neurosurgery 略　 称：Clin Neurol Neurosurg ISSNコード：18726968/03038467
掲載区分	国外
巻・号・頁	125,pp.217-221
著者・共著者	Ikeguchi Ryotaro†, Shimizu Yuko, Suzuki Shigeaki, Shimizu Satoru, Kabasawa Chiaki, Hashimoto Shiori, Masuda Masayuki, Nagane Yuriko, Utsugisawa Kimiaki, Suzuki Yasushi, Takahashi Toshiyuki, Utsumi Hiroya, Fujihara Kazuo, Suzuki Norihiro, Uchiyama Shinichiro
発行年月	2014/10
概要	BACKGROUND:The incidence of concurrent myasthenia gravis (MG) and neuromyelitis optica spectrum disorder (NMOSD) is higher than what chance predicts, yet it remains unclear why MG and NMOSD appear concurrently.OBJECTIVE:The purpose of the present study was to examine the clinical features of the concurrence of these diseases.METHODS:Clinical details were analyzed retrospectively.RESULTS:Three (0.5%) out of 631 MG patients had confirmed (n=2) or suspected (n=1) NMOSD. Two of these patients were women. All showed early-onset MG (EOMG) that preceded NMOSD and were positive for acetylcholine receptor antibody (AChR-Ab). Two patients were tested for aquaporin 4 antibody (AQP4-Ab) and were positive. Two patients were treated with a thymectomy that preceded NMOSD. Two patients had decreased frequency of regulatory T (Treg) cells. We identified in the literature 46 patients with both MG and NMOSD. Our results of female predominance, EOMG, MG preceding NMOSD, and positive AChR-Ab are consistent with previous descriptions.CONCLUSIONS:This is the first report to examine the frequency of NMOSD in Japanese patients with MG. The reduction and/or dysfunction of Treg cells may be one cause of NMOSD development in MG.
DOI	10.1016/j.clineuro.2014.07.036
PMID	25178916