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小笠原 壽恵
Department School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine Position Assistant Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | JAK2-negative acute monocytic leukemia with TET2 mutation in essential thrombocythemia with JAK2 mutation with literature review |
| Journal | Formal name：Leukemia Ressarch Reports |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | pp.1 |
| Author and coauthor | Toshie Ogasawara, Kiyotaka Kawauchi, Takuya Ono, Shoko Marshall, Kotaro Shide, Kazuya Shimoda, Naoki Mori,Hiroshi Sakura |
| Publication date | 2020/01/16 |
| Summary | Essential thrombocythemia (ET) is an indolent myeloproliferative neoplasm (MPN) with a transformation to acute myeloid leukemia in <5% of patients. A 79-year-old man with JAK2V617F-positive ET exhibited leukocytosis with an increase in monoblastic cells, leading to a diagnosis of acute monoblastic and monocytic leukemia. Leukemic cells carried a TET2 mutation but not JAK2V617F mutation. We concluded that the TET2 mutation occurred in MPN-initiating cells and overcame JAK2-mutated cells. The absence of a JAK2 mutation in the leukemic cells in this case suggests the leukemia emerged from a JAK2-negative MPN cell clone carrying the TET2 mutation. |
| DOI | doi.org/10.1016/j.lrr.2019.100194 |