ナンケ　ユキ   Nanke Yuki   南家　由紀    所属   看護学部 看護学科    職種   教授
論文種別	総説
言語種別	英語
査読の有無	査読あり
表題	The Plasticity of Th17 Cells in the Pathogenesis of Rheumatoid Arthritis.
掲載誌名	正式名：Journal of clinical medicine 略　 称：J Clin Med ISSNコード：(2077-0383)2077-0383(Linking)
掲載区分	国外
巻・号・頁	6(7),pp.piiE67
著者・共著者	Kotake Shigeru, Yago Toru, Kobashigawa Tsuyoshi, Nanke Yuki
発行年月	2017/07
概要	Helper T (Th) cells play an important role in the pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). It has been revealed that Th17 cells can shift to Th1 cells (i.e., "nonclassic Th1 cells"), which are reported to be more pathogenic than Th17 cells per se. Thus, the association of Th cells in the pathogenesis of autoimmune disease has become more complicated. We recently reported using peripheral blood from untreated and early-onset RA patients that the ratio of CD161+Th1 cells (i.e., Th17-derived Th1 cells to CD161+Th17 cells) is elevated and that levels of interferon-γ (IFNγ)+Th17 cells are inversely correlated with levels of anti-CCP antibodies. Here, we review the plasticity of Th17 cells in the pathogenesis of RA, suggesting possible implications for novel therapies.
DOI	10.3390/jcm6070067
PMID	28698517