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Nanke Yuki
Department School of Nursing, School of Nursing Position Professor |
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| Article types | Case report |
| Language | English |
| Peer review | Peer reviewed |
| Title | Progressive appearance of overlap syndrome together with autoantibodies in a patient with fatal thrombotic microangiopathy. |
| Journal | Formal name：The American journal of the medical sciences Abbreviation：Am J Med Sci ISSN code：(0002-9629)0002-9629(Linking) |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 320(5),pp.348-51 |
| Author and coauthor | Nanke Y, Akama H, Yamanaka H, Hara M, Kamatani N |
| Publication date | 2000/11 |
| Summary | We describe an extraordinary patient with overlap syndrome (systemic lupus erythematosus, systemic sclerosis, and rheumatoid arthritis) having positive autoantibodies against Sm, double stranded DNA, DNA topoisomerase I, and centromere, together with rheumatoid factor. The patient had multiple organ involvement resulting from thrombotic microangiopathy that mimicked so-called normotensive scleroderma renal crisis, and died mainly of massive pulmonary hemorrhage caused by thrombotic thrombocytopenic purpura. The clinical presentations of the case support the concept of strong associations between disease-specific autoantibodies and clinical features. |
| DOI | 10.1097/00000441-200011000-00010 |
| PMID | 11093690 |