TAKANASHI JUN-ICHI    Department   School of Medicine(Yachiyo Medical Center), School of Medicine    Position   Professor
Article types	Case report
Language	Japanese
Peer review	Peer reviewed
Title	A case of anti-MOG antibody-positive multiphasic disseminated encephalomyelitis co-occurring with unilateral cerebral cortical encephalitis
Domestic / Foregin	Domestic
Volume, Issue, Page	57(11),pp.723-728
Author and coauthor	Naoya Fukushima†, Miki Suzuki, Ryo Ogawa, Kitami Hayashi, Jun-ichi Takanashi, Takashi Ohashi*
Publication date	2017/11
Summary	A 20-year-old woman first developed acute disseminated encephalomyelitis (ADEM) at 11 years of age. At 17 years of age, she was hospitalized due to generalized seizure and diagnosed with encephalitis. Brain MRI revealed a FLAIRhyperintense lesion in the unilateral cerebral cortex. At 18 years of age, serum anti-myelin oligodendrocyte glycoprotein (MOG) antibody was detected. At 20 years of age, she was admitted to our hospital, diagnosed with multifocal disseminated encephalomyelitis (MDEM). MDEM has been observed in patients that are seropositive for the anti-MOG antibody. More recently, unilateral cerebral cortex encephalitis with epilepsy has also been reported in such patients. The co-occurrence of MDEM and cortical encephalitis in the same patient has important implications for the pathogenesis of anti-MOG antibody-associated autoimmune diseases.
DOI	10.5692/clinicalneurol.cn-001078