OHKI Takeshi
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Associate Professor
Article types Review article
Language English
Peer review Non peer reviewed
Title Esophageal regenerative therapy using cell sheet technology.
Journal Formal name:Regenerative therapy
Abbreviation:Regen Ther
ISSN code:23523204/23523204
Domestic / ForeginForegin
Volume, Issue, Page 13,pp.8-17
Author and coauthor OHKI Takeshi, YAMAMOTO Masakazu
Authorship Lead author
Publication date 2020/03
Summary We have been conducting research on esophageal regenerative therapy using cell sheet technology. In particular, in the endoscopic field, we have pushed forward clinical research on endoscopic transplantation of cultured autologous oral mucosal epithelial cell sheets to esophageal ulcer after endoscopic submucosal dissection (ESD). We started research in this direction using animal models in 2004 and performed clinical research in 2012 in collaboration with Nagasaki University and Karolinska Institute. Although in full-circumferential cases it was difficult to prevent esophageal stricture after ESD, there were no complications and stricture could be suppressed. The cell sheet technology is still in its infancy. However, we are convinced that it has a high potential for application in various areas of gastrointestinal science. In this review, we focus on the pre-clinical and clinical trial results obtained and on the theoretical aspects of (1) stricture prevention, (2) esophageal tissue engineering research, and (3) endoscopic transplantation, and review the esophageal regenerative therapy by cell sheet technology.
DOI 10.1016/j.reth.2020.04.009
PMID 33490318