KEN OKAZAKI    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor and Division head
Article types	Case report
Language	English
Peer review	Peer reviewed
Title	Methotrexate-Related Lymphoproliferative Disorder Presenting with Severe Swelling of the Elbow Joint: A Case Report.
Journal	Formal name：JBJS case connector Abbreviation：JBJS Case Connect ISSN code：21603251/21603251
Domestic / Foregin	Foregin
Volume, Issue, Page	7(3),pp.e65
Author and coauthor	Hatano Takashi, Ohishi Masanobu, Yoshimoto Goichi, Yamauchi Moriyasu, Maekawa Akira, Yamamoto Hidetaka, Oda Yoshinao, Endo Makoto, Bekki Hirofumi, Matsunobu Tomoya, Nakashima Yasuharu, Okazaki Ken, Fukushi Jun-Ichi, Oyamada Akiko, Iwamoto Yukihide
Publication date	2017/07
Summary	CASE:A patient with rheumatoid arthritis (RA) who was being treated with methotrexate (MTX) therapy presented with severe swelling of the left elbow. Magnetic resonance imaging showed a tumor-like lesion around the elbow joint. Fluorodeoxyglucose positron emission tomography indicated multiple lesions in the lung and the lymph nodes. An open biopsy of a cervical lymph node was performed, and MTX-related lymphoproliferative disorder (MTX-LPD) was diagnosed. After cessation of the MTX therapy, the elbow swelling regressed, and the patient was in remission of MTX-LPD.CONCLUSION:MTX-LPD should be considered in the differential diagnosis when a patient with RA develops severe joint swelling while on MTX therapy.
DOI	10.2106/JBJS.CC.17.00002
PMID	29252894