IKUTA Soko    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position
Article types	Case report
Language	English
Peer review	Peer reviewed
Title	Usefulness of positron emission tomography for differentiating gliomas according to the 2016 World Health Organization classification of tumors of the central nervous system.
Journal	Formal name：Journal of neurosurgery Abbreviation：J Neurosurg ISSN code：19330693/00223085
Domestic / Foregin	Domestic
Volume, Issue, Page	133(4),pp.947-1284
Author and coauthor	TAKEI Hiroaki†, SHINODA Jun, IKUTA Soko, MARUYAMA Takashi, MURAGAKI Yoshihiro, KAWASAKI Tomohiro, IKEGAME Yuka, OKADA Makoto, ITO Takeshi,, ASANO Yoshitaka, YOKOYAMA Kazutoshi, NAKAYAMA Noriyuki, YANO Hirohito, IWAMA Toru
Publication date	2019/08/16
Summary	OBJECTIVE:Positron emission tomography (PET) is important in the noninvasive diagnostic imaging of gliomas. There are many PET studies on glioma diagnosis based on the 2007 WHO classification; however, there are no studies on glioma diagnosis using the new classification (the 2016 WHO classification). Here, the authors investigated the relationship between uptake of 11C-methionine (MET), 11C-choline (CHO), and 18F-fluorodeoxyglucose (FDG) on PET imaging and isocitrate dehydrogenase (IDH) status (wild-type [IDH-wt] or mutant [IDH-mut]) in astrocytic and oligodendroglial tumors according to the 2016 WHO classification.METHODS:In total, 105 patients with newly diagnosed cerebral gliomas (6 diffuse astrocytomas [DAs] with IDH-wt, 6 DAs with IDH-mut, 7 anaplastic astrocytomas [AAs] with IDH-wt, 24 AAs with IDH-mut, 26 glioblastomas [GBMs] with IDH-wt, 5 GBMs with IDH-mut, 19 oligodendrogliomas [ODs], and 12 anaplastic oligodendrogliomas [AOs]) were included. All OD and AO patients had both IDH-mut and 1p/19q codeletion. The maximum standardized uptake value (SUV) of the tumor/mean SUV of normal cortex (T/N) ratios for MET, CHO, and FDG were calculated, and the mean T/N ratios of DA, AA, and GBM with IDH-wt and IDH-mut were compared. The diagnostic accuracy for distinguishing gliomas with IDH-wt from those with IDH-mut was assessed using receiver operating characteristic (ROC) curve analysis of the mean T/N ratios for the 3 PET tracers.RESULTS:There were significant differences in the mean T/N ratios for all 3 PET tracers between the IDH-wt and IDH-mut groups of all histological classifications (p < 0.001). Among the 27 gliomas with mean T/N ratios higher than the cutoff values for all 3 PET tracers, 23 (85.2%) were classified into the IDH-wt group using ROC analysis. In DA, there were no significant differences in the T/N ratios for MET, CHO, and FDG between the IDH-wt and IDH-mut groups. In AA, the mean T/N ratios of all 3 PET tracers in the IDH-wt group were significan
DOI	10.3171/2019.5.JNS19780
PMID	31419796