HANAFUSA Norio
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Professor
Article types Original article
Language English
Peer review Peer reviewed
Title The uric acid-urea distribution volume ratio is a potential marker of hydration status in patients on hemodialysis.
Journal Formal name:Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs
Abbreviation:J Artif Organs
ISSN code:16190904/14347229
Domestic / ForeginForegin
Volume, Issue, Page pp.10.1007/s10047-022-01377-6.-10.1007/s10047-022-01377-6.
Author and coauthor Kawaguchi Yuki, Hanafusa Norio, Sakurai Satoko, Miyaji Mai, Toda Naohiro, Iwadoh Kazuhiro, Tsuchiya Ken
Authorship 2nd author,Corresponding author
Publication date 2022/12
Summary The distribution volume of uric acid is affected by the amount of extracellular water (ECW), while urea distribution volume can be considered as total body water (TBW). Thus, the ratio of distribution volumes of uric acid and urea can be paralleled to and be considered as the proxy of ECW/TBW. A total of 108 patients at our facility was included. The uric acid and urea distribution volume ratio (UUVdR) calculated from the single-pool model, which was measured within 1 month of the time when the bioimpedance index was measured. ECW/TBW at the end of the HD session was measured by InBody S10. We investigated the association between the UUVdR and the ECW/TBW values and the factors affecting the residuals of the regression equation. We also evaluated the predictive ability of overhydration or dehydration in randomly selected two groups, i.e., the training group and the validation group. ECW/TBW correlated highly with UUVdR. Multivariate analysis demonstrated that only creatinine and ECW/TBW were significantly associated with regression residuals. The cutoff values of UUVdR for overhydration and dehydration were 0.666 and 0.579, respectively, in the training group. Their AUC were 0.872 and 0.898, respectively. The sensitivity and specificity values in the validation group were 0.571 and 0.868 for overhydration, and 0.444 and 0.953 for dehydration, respectively. UUVdR might be a proxy of hydration status in hemodialysis patients. It may be possible to predict hydration status without dedicated devices in the epidemiological study.
DOI 10.1007/s10047-022-01377-6
PMID 36565326