HANAFUSA Norio    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Effectiveness of SARS-CoV-2 vaccines on hemodialysis patients in Japan: A nationwide cohort study.
Journal	Formal name：Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Abbreviation：Ther Apher Dial ISSN code：17449987/17449979
Domestic / Foregin	Foregin
Volume, Issue, Page	pp.online
Author and coauthor	Kikuchi Kan, Nangaku Masaomi, Ryuzaki Munekazu, Yamakawa Tomoyuki, Yoshihiro Ota, Hanafusa Norio, Sakai Ken, Kanno Yoshihiko, Ando Ryoichi, Shinoda Toshio, Wakino Shu, Nakamoto Hidetomo, Takemoto Yoshiaki, Akizawa Tadao,
Publication date	2022/05
Summary	INTRODUCTION:This study compared the outcomes of dialysis patients who received SARS-CoV-2 vaccine with those who did not use data from the Japanese COVID-19 registry.METHODS:A total of 1260 dialysis patients with confirmed positive SARS-CoV-2 infection was included in this study. Patients were divided into two groups: patients who experienced breakthrough infection and those who were unvaccinated. The need of oxygen supplementation and mortality risks were compared using multivariate logistic regression analysis.RESULTS:The mortality rate was 24.2% in unvaccinated patients and 8.6% in breakthrough patients. The odds ratio of need of oxygen supplementation in the breakthrough patients relative to unvaccinated patients was 0.197. The hazard ratio of mortality in the breakthrough patients relative to unvaccinated patients was 0.464.CONCLUSION:Our prospective observational study showed that SRAS-CoV-2 vaccination in hemodialysis patients is vital for reducing need of oxygen supplementation and mortality risk.
DOI	10.1111/1744-9987.13887
PMID	35610734