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IWASAKI Masayuki
Department Research Institutes and Facilities, Research Institutes and Facilities Position Assistant Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis. |
| Journal | Formal name：Cancer cell Abbreviation：Cancer Cell ISSN code：18783686/15356108 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 17(6),pp.597-608 |
| Author and coauthor | Wang Zhong, Iwasaki Masayuki, Ficara Francesca, Lin Chenwei, Matheny Christina, Wong Stephen H K, Smith Kevin S, Cleary Michael L |
| Authorship | 2nd author |
| Publication date | 2010/06 |
| Summary | Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. |
| DOI | 10.1016/j.ccr.2010.04.024 |
| PMID | 20541704 |