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イワサキ マサユキ
IWASAKI Masayuki
岩崎 正幸 所属 研究施設 研究施設 職種 講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. |
| 掲載誌名 | 正式名：Cell stem cell 略 称：Cell Stem Cell ISSNコード：18759777/18759777 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 4(2),pp.129-40 |
| 著者・共著者 | Somervaille Tim C P, Matheny Christina J, Spencer Gary J, Iwasaki Masayuki, Rinn John L, Witten Daniela M, Chang Howard Y, Shurtleff Sheila A, Downing James R, Cleary Michael L |
| 発行年月 | 2009/02 |
| 概要 | The genetic programs that promote retention of self-renewing leukemia stem cells (LSCs) at the apex of cellular hierarchies in acute myeloid leukemia (AML) are not known. In a mouse model of human AML, LSCs exhibit variable frequencies that correlate with the initiating MLL oncogene and are maintained in a self-renewing state by a transcriptional subprogram more akin to that of embryonic stem cells (ESCs) than to that of adult stem cells. The transcription/chromatin regulatory factors Myb, Hmgb3, and Cbx5 are critical components of the program and suffice for Hoxa/Meis-independent immortalization of myeloid progenitors when coexpressed, establishing the cooperative and essential role of an ESC-like LSC maintenance program ancillary to the leukemia-initiating MLL/Hox/Meis program. Enriched expression of LSC maintenance and ESC-like program genes in normal myeloid progenitors and poor-prognosis human malignancies links the frequency of aberrantly self-renewing progenitor-like cancer stem cells (CSCs) to prognosis in human cancer. |
| DOI | 10.1016/j.stem.2008.11.015 |
| PMID | 19200802 |