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IIZUKA Junpei
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Associate Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Radical Prostatectomy for Localized Prostate Cancer in Renal Transplant Recipients: 13 Cases Studied at a Single Center. |
| Journal | Formal name：Transplantation proceedings Abbreviation：Transplant Proc ISSN code：18732623/00411345 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 50(8),pp.2539-2544 |
| Author and coauthor | Iwamoto K, Iizuka J*, Hashimoto Y, Kondo T, Takagi T, Hata K, Unagami K, Okumi M, Ishida H, Tanabe K |
| Authorship | 2nd author,Corresponding author |
| Publication date | 2018/10 |
| Summary | OBJECTIVES:We aimed to evaluate the feasibility and efficacy of surgical prostatectomy in renal transplant recipients (RTRs).METHODS:Between January 2008 and February 2017, we identified 13 RTRs who were diagnosed with localized prostate cancer and underwent radical prostatectomy. We reviewed all available clinicopathologic data for these 13 patients.RESULTS:The median patient age was 61 years and median serum prostate-specific antigen (PSA) was 8.79 ng/mL. The mean period between transplantation and diagnosis of prostate cancer was 136 months. The sources for the kidney transplants included 10 living and 3 deceased donors. Biopsies indicated that the Gleason scores were 7 in 10 patients and 8 to 10 in 3 patients. Meanwhile, the D'Amico risk classification indicated an intermediate risk in 9 patients and a high risk in 4 patients. Eight patients were at stage cT1 and 5 were at stage cT2. The surgical procedure was retropubic radical prostatectomy in one recipient, laparoscopic radical prostatectomy in 3 recipients, and robot-assisted radical prostatectomy in 9 RTRs. Intraoperative complications were not noted in any patient, although one patient demonstrated postoperative complications (Clavien grade ≥ 3). An indwelling urinary catheter was required in 3 patients for over 3 weeks due to delayed wound healing. Biochemical recurrence evaluated by PSA monitoring occurred in four patients. Postoperative graft function was stable in all but one patient who required resumption of dialysis before prostatectomy; however, all patients are alive at the time of publication with 12 patients showing well-functioning renal allografts.CONCLUSION:Prostatectomy may be a feasible and effective technique as an initial treatment for RTRs with localized prostate cancer. |
| DOI | 10.1016/j.transproceed.2018.03.029 |
| PMID | 30316394 |