イイヅカ　ジユンペイ   IIZUKA Junpei   飯塚　淳平    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Radical Prostatectomy for Localized Prostate Cancer in Renal Transplant Recipients: 13 Cases Studied at a Single Center.
掲載誌名	正式名：Transplantation proceedings 略　 称：Transplant Proc ISSNコード：18732623/00411345
掲載区分	国外
巻・号・頁	50(8),pp.2539-2544
著者・共著者	Iwamoto K, Iizuka J*, Hashimoto Y, Kondo T, Takagi T, Hata K, Unagami K, Okumi M, Ishida H, Tanabe K
担当区分	2nd著者,責任著者
発行年月	2018/10
概要	OBJECTIVES:We aimed to evaluate the feasibility and efficacy of surgical prostatectomy in renal transplant recipients (RTRs).METHODS:Between January 2008 and February 2017, we identified 13 RTRs who were diagnosed with localized prostate cancer and underwent radical prostatectomy. We reviewed all available clinicopathologic data for these 13 patients.RESULTS:The median patient age was 61 years and median serum prostate-specific antigen (PSA) was 8.79 ng/mL. The mean period between transplantation and diagnosis of prostate cancer was 136 months. The sources for the kidney transplants included 10 living and 3 deceased donors. Biopsies indicated that the Gleason scores were 7 in 10 patients and 8 to 10 in 3 patients. Meanwhile, the D'Amico risk classification indicated an intermediate risk in 9 patients and a high risk in 4 patients. Eight patients were at stage cT1 and 5 were at stage cT2. The surgical procedure was retropubic radical prostatectomy in one recipient, laparoscopic radical prostatectomy in 3 recipients, and robot-assisted radical prostatectomy in 9 RTRs. Intraoperative complications were not noted in any patient, although one patient demonstrated postoperative complications (Clavien grade ≥ 3). An indwelling urinary catheter was required in 3 patients for over 3 weeks due to delayed wound healing. Biochemical recurrence evaluated by PSA monitoring occurred in four patients. Postoperative graft function was stable in all but one patient who required resumption of dialysis before prostatectomy; however, all patients are alive at the time of publication with 12 patients showing well-functioning renal allografts.CONCLUSION:Prostatectomy may be a feasible and effective technique as an initial treatment for RTRs with localized prostate cancer.
DOI	10.1016/j.transproceed.2018.03.029
PMID	30316394