コバヤシ　ヒロヒト   KOBAYASHI Hirohito   小林　博人    所属   医学部 医学科（附属足立医療センター）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Gamma/delta T cells provide innate immunity against renal cell carcinoma.
掲載誌名	正式名：Cancer immunology, immunotherapy : CII 略　 称：Cancer Immunol Immunother ISSNコード：03407004/03407004
掲載区分	国外
巻・号・頁	50(3),pp.115-124
著者・共著者	Kobayashi H, Tanaka Y, Yagi J, Toma H, Uchiyama T
担当区分	筆頭著者
発行年月	2001/05
概要	Host immune function plays a certain role against the development of renal cell carcinomas (RCCs), but the mechanism is not entirely understood. Human gamma/delta (gamma/delta) T cells defend the body against infection. In this study, we clarify the role of gamma/delta T cells in the surveillance system against RCCs by analyzing the gamma/delta T cells in peripheral blood mononucleocytes (PBMs) and tumor infiltrating lymphocytes (TILs) from 41 patients with RCCs. The results showed that the number of gamma/delta T cells expressing V gamma 2 and V delta 2 in variable elements of TCR was elevated in the PBMs in 10 patients, but not in any of 32 healthy individuals. The proportion of patients with an elevated number of gamma/delta T cells (> 10%) increased with cancer stage. The level of the gamma/delta T cells decreased after surgery. The gamma/delta T cells in the TILs were more activated than those in the PBMs. Evaluation of the junctional diversity of TCR V gamma 2 and V delta 2 chains showed that the increased peripheral blood gamma/delta T cells were oligoclonal rather than polyclonal. Taken together, our findings suggest that gamma/delta T cells recognize certain RCC-related antigens and play a role in the surveillance system against RCCs.
DOI	10.1007/s002620100173
PMID	11419178