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KOBAYASHI Hirohito
Department School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine Position Associate Professor |
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| Article types | Case report |
| Language | English |
| Peer review | Peer reviewed |
| Title | Complete remission of lung metastasis following adoptive immunotherapy using activated autologous gammadelta T-cells in a patient with renal cell carcinoma. |
| Journal | Formal name：Anticancer research Abbreviation：Anticancer Res ISSN code：17917530/02507005 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 30(2),pp.575-579 |
| Author and coauthor | Kobayashi Hirohito, Tanaka Yoshimasa, Shimmura Hiroaki, Minato Nagahiro, Tanabe Kazunari |
| Authorship | Lead author |
| Publication date | 2010/02 |
| Summary | BACKGROUND:gammadelta T-cells have recently attracted considerable attention in the development of novel cancer immunotherapy, and several different approaches have been designed and employed in clinical trials.CASE REPORT:A patient with lung metastasis after radical nephrectomy for renal cell carcinoma had six cycles of adoptive immunotherapy using autologous in vitro-activated gammadelta T-cells followed by low-dose interleukin-2 and zoledronic acid intravenous infusion. Complete remission was achieved which has been maintained for 2 years without any additional treatment. Immunological analysis demonstrated a high level of interferon-gamma four hours through one day following the transfer and peripheral blood gammadelta T-cells increased 10-fold from the baseline value, 7 days after the transfer. No serious adverse events were observed.CONCLUSION:Adoptive immunotherapy using gammadelta T-cells was shown here to be clinically beneficial and safe, and may become a therapeutic option for patients with advanced RCC. |
| DOI | 10.21873/anticanres |
| PMID | 20332473 |