AKIMASA ICHINOE
Department School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine Position Assistant Professor |
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Article types | Original article |
Language | English |
Peer review | Peer reviewed |
Title | Retrospective Analysis of Concurrent Chemoradiation with Triweekly Cisplatin plus 5-Fluorouracil Versus Weekly Cisplatin in Cervical Cancer. |
Journal | Formal name:Anticancer research Abbreviation:Anticancer Res ISSN code:02507005/17917530 |
Volume, Issue, Page | 35(6),pp.3447-3454 |
Author and coauthor | KENZO SONODA†, HIDEAKI YAHATA, AKIMASA ICHINOE, KAORU OKUGAWA, EISUKE KANEKI, YOSHIAKI KAWANO, HIRONORI KENJO, TATSUHIRO OHGAMI, HIROSHI YAGI, SAIJI OHGA, KAORI ASAI, KATSUMASA NAKAMURA, HIROSHI HONDA, KIYOKO KATO* |
Publication date | 2015 |
Summary | Background/Aim: Concurrent chemoradiation
(CCRT) is the standard treatment for locally advanced cervical cancer. The purpose of the study was to compare the outcomes of triweekly cisplatin plus 5-fluorouracil and weekly cisplatin regimens. Patients and Methods: We retrospectively reviewed data from 91 patients with stage IB1-IVA cervical cancer. Results: Out of 91 patients, 48 received triweekly CCRT and 43 received weekly CCRT. For triweekly CCRT, patients received a median of two chemotherapy cycles and median total doses of cisplatin and 5-fluorouracil were 210 mg/body and 8,525 mg/body, respectively. For weekly CCRT, patients received a median of five chemotherapy cycles and the median total dose of cisplatin was 252 mg/body. No statistically significant differences in overall survival or progression-free survival were noted between the two groups. Conclusion: Both triweekly CCRT and weekly CCRT appear to have similar efficacy for cervical cancer patients, but the toxicities were better tolerable in weekly CCRT. |