ヨシナガ ケンタロウ
KENTARO YOSHINAGA
吉永 健太郎 所属 医学部 医学科(東京女子医科大学病院) 職種 講師 |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Very Early Increased Platelet Count within a Week after Initiation of High-Dose Dexamethasone Treatment Is Associated with Long-Term Response in Newly Diagnosed Immune Thrombocytopenia Patients. |
掲載誌名 | 正式名:Acta haematologica 略 称:Acta Haematol ISSNコード:14219662/00015792 |
掲載区分 | 国外 |
巻・号・頁 | 145(2),pp.193-200 |
著者・共著者 | Ishiyama Midori†, Shiseki Masayuki, Yoshinaga Kentaro, Ryuzaki Michiko, Izuka Yuki, Watanabe Aya, Tanaka Norina, Shinohara Akihito, Hagiwara Shotaro, Tanaka Junji |
発行年月 | 2022/02 |
概要 | To evaluate the long-term efficacy of high-dose dexamethasone (HD-DXM) treatment for immune thrombocytopenia (ITP), we retrospectively analysed 36 newly diagnosed ITP patients treated with HD-DXM as a first-line treatment. An initial response was obtained in 23 (63.9%) patients, including 11 with a complete response (CR) and 12 with a partial response (PR). Six months after HD-DXM treatment, 26 of 33 (78.8%) evaluable patients achieved objective responses, including 18 CR and 8 PR. Among 13 patients without initial response, very early increased platelet count within a week (VEIP) was observed in 7 patients, 5 (71.4%) of whom achieved a response at 6 months. In 29 patients who had available platelet count within a week, patients showing VEIP revealed longer survival than those who did not (p = 0.026). HD-DXM was an effective treatment for newly diagnosed ITP patients. VEIP after HD-DXM treatment initiation was associated with a long-term objective response in newly diagnosed ITP patients. |
DOI | 10.1159/000518744 |
PMID | 34818223 |