ヨシナガ ケンタロウ
KENTARO YOSHINAGA
吉永 健太郎 所属 医学部 医学科(東京女子医科大学病院) 職種 講師 |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | High PRAME expression is associated with poor survival and early disease progression in myelodysplastic syndromes with a low bone marrow blast percentage. |
掲載誌名 | 正式名:Leukemia & lymphoma 略 称:Leuk Lymphoma ISSNコード:10292403/10268022 |
掲載区分 | 国外 |
巻・号・頁 | 62(10),pp.2448-2456 |
著者・共著者 | Shiseki Masayuki†*, Ishii Mayuko, Ohwashi Mari, Wang Yan-Hua, Tanaka Norina, Osanai Satoko, Yoshinaga Kentaro, Mori Naoki, Tanaka Junji |
発行年月 | 2021/10 |
概要 | We investigated the clinical implications of preferentially expressed antigen in melanoma (PRAME) expression in bone marrow cells of 116 patients with myelodysplastic syndromes (MDS). Quantitative RT-PCR was carried out to examine the PRAME expression level. High PRAME expression was observed in MDS patients classified into higher revised International Prognostic Scoring System (IPSS-R) risk categories (Very high and High) with a high bone marrow blast percentage (5% or higher). Kaplan-Meier analysis demonstrated that high PRAME expression is significantly associated with a poorer overall survival (OS) in MDS patients with a low bone marrow blast percentage (less than 5%) (log-rank test p = .0014) and those classified into lower IPSS-R risk categories (Very Low, Low, and Intermediate) (log-rank test, p = .0035). In contrast, there was no significant association between PRAME expression and OS in MDS patients with a high bone marrow blast percentage or those classified into higher IPSS-R risk categories. In addition, high PRAME expression was associated with early disease progression in MDS patients with a low bone marrow blast percentage. This study suggested PRAME expression to be a prognostic factor in MDS. |
DOI | 10.1080/10428194.2021.1919659 |
PMID | 34013846 |