ハヤシ　モトヒロ   HAYASHI Motohiro   林　基弘    所属   医学部 医学科（東京女子医科大学病院）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Malignant progression of benign brain tumors after gamma knife radiosurgery: is it really caused by irradiation?
掲載誌名	正式名：Minim Invasive Neurosurg ISSNコード：09467211
掲載区分	国外
出版社	© Georg Thieme Verlag Stuttgart · New York
巻・号・頁	48(6),pp.334-339
著者・共著者	KUBO Osami, CHERNOV Mikhail, IZAWA Masahiro, HAYASHI Motohiro, MURAGAKI Yoshihiro†, MARUYAMA Takashi, HORI Tomokatsu, TAKAKURA Kintomo
発行年月	2005/12
概要	Malignant transformation of benign neoplasm after radiosurgery is usually diagnosed based on the initial presence of benign tumor, its exposure to ionizing radiation, elapsed time from radiation exposure to malignant progression, and different histological characteristics or growth rate of the regrowing tumor comparing with those originally treated. Three presented cases fulfilled these diagnostic criteria; however, it seems that progression of the tumors (schwannoma, meningioma, chordoma) resulted from the natural course of the disease, rather than represented side effects of gamma knife radiosurgery. Evaluation of the proliferative potential of the benign neoplasm before radiosurgical treatment either directly, if tumor sampling is available, or indirectly, by calculation of the tumor growth rate and/or analysis of the data of the metabolic imaging (PET, MRS) is important for identification of"aggressive"subtypes, precise prediction of prognosis, and confirmation of the radiation-induced malignant transformation in cases of tumor regrowth.
DOI	10.1055/s-2005-915632
PMID	16432782