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UTSUGISAWA Taiju
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Associate Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Function for p300 and not CBP in the apoptotic response to DNA damage. |
| Journal | Formal name：Oncogene Abbreviation：Oncogene ISSN code：09509232/09509232 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 18(41),pp.5714-5717 |
| Author and coauthor | Yuan Z M, Huang Y, Ishiko T, Nakada S, Utsugisawa T, Shioya H, Utsugisawa Y, Shi Y, Weichselbaum R, Kufe D |
| Publication date | 1999/10 |
| Summary | The cellular response to ionizing radiation (IR) includes the induction of apoptosis. The p300/CBP proteins possess histone acetyltransferase activity and function as transcriptional coactivators of p53. We have prepared cells deficient in p300 or CBP to define the roles of these proteins in the cellular response to DNA damage. The present results demonstrate that p300, but not CBP, contributes to IR sensitivity of cells. The results also demonstrate that IR-induced apoptosis is impaired in the p300-, but not CBP-, deficient cells. These findings indicate that p300 functions in the apoptotic response to DNA damage. |
| DOI | 10.1038/sj.onc.1202930 |
| PMID | 10523850 |