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UTSUGISAWA Taiju
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Associate Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Role for p300 in stabilization of p53 in the response to DNA damage. |
| Journal | Formal name：The Journal of biological chemistry Abbreviation：J Biol Chem ISSN code：00219258/00219258 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 274(4),pp.1883-1886 |
| Author and coauthor | Yuan Z M, Huang Y, Ishiko T, Nakada S, Utsugisawa T, Shioya H, Utsugisawa Y, Yokoyama K, Weichselbaum R, Shi Y, Kufe D |
| Publication date | 1999/01 |
| Summary | The nuclear p300/CBP proteins function as coactivators of gene transcription. Here, using cells deficient in p300 or CBP, we show that p300, and not CBP, is essential for ionizing radiation-induced accumulation of the p53 tumor suppressor and thereby p53-mediated growth arrest. The results demonstrate that deficiency of p300 results in increased degradation of p53. Our findings suggest that p300 contributes to the stabilization and transactivation function of p53 in the cellular response to DNA damage. |
| DOI | 10.1074/jbc.274.4.1883 |
| PMID | 9890940 |