ウツギサワ タイジユ   UTSUGISAWA Taiju
  槍澤 大樹
   所属   医学部 医学科(東京女子医科大学病院)
   職種   講師
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Role for p300 in stabilization of p53 in the response to DNA damage.
掲載誌名 正式名:The Journal of biological chemistry
略  称:J Biol Chem
ISSNコード:00219258/00219258
掲載区分国外
巻・号・頁 274(4),pp.1883-1886
著者・共著者 Yuan Z M, Huang Y, Ishiko T, Nakada S, Utsugisawa T, Shioya H, Utsugisawa Y, Yokoyama K, Weichselbaum R, Shi Y, Kufe D
発行年月 1999/01
概要 The nuclear p300/CBP proteins function as coactivators of gene transcription. Here, using cells deficient in p300 or CBP, we show that p300, and not CBP, is essential for ionizing radiation-induced accumulation of the p53 tumor suppressor and thereby p53-mediated growth arrest. The results demonstrate that deficiency of p300 results in increased degradation of p53. Our findings suggest that p300 contributes to the stabilization and transactivation function of p53 in the cellular response to DNA damage.
DOI 10.1074/jbc.274.4.1883
PMID 9890940