UTSUGISAWA Taiju
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Associate Professor |
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Article types | Original article |
Language | English |
Peer review | Peer reviewed |
Title | Activation of protein kinase C delta by the c-Abl tyrosine kinase in response to ionizing radiation. |
Journal | Formal name:Oncogene Abbreviation:Oncogene ISSN code:09509232/09509232 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 16(13),pp.1643-1648 |
Author and coauthor | Yuan Z M, Utsugisawa T, Ishiko T, Nakada S, Huang Y, Kharbanda S, Weichselbaum R, Kufe D |
Authorship | 2nd author |
Publication date | 1998/04 |
Summary | The c-Abl protein tyrosine kinase is activated by ionizing radiation (IR) and certain other DNA-damaging agents. The present studies demonstrate that c-Abl associates constitutively with protein kinase C delta (PKCdelta). The results show that the SH3 domain of c-Abl interacts directly with PKCdelta. c-Abl phosphorylates and activates PKCdelta in vitro. We also show that IR treatment of cells is associated with c-Abl-dependent phosphorylation of PKCdelta and translocation of PKCdelta to the nucleus. These findings support a functional interaction between c-Abl and PKCdelta in the cellular response to genotoxic stress. |
DOI | 10.1038/sj.onc.1201698 |
PMID | 9582011 |