UTSUGISAWA Taiju
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Assistant Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Activation of protein kinase C delta by the c-Abl tyrosine kinase in response to ionizing radiation.
Journal Formal name:Oncogene
Abbreviation:Oncogene
ISSN code:09509232/09509232
Domestic / ForeginForegin
Volume, Issue, Page 16(13),pp.1643-1648
Author and coauthor Yuan Z M, Utsugisawa T, Ishiko T, Nakada S, Huang Y, Kharbanda S, Weichselbaum R, Kufe D
Authorship 2nd author
Publication date 1998/04
Summary The c-Abl protein tyrosine kinase is activated by ionizing radiation (IR) and certain other DNA-damaging agents. The present studies demonstrate that c-Abl associates constitutively with protein kinase C delta (PKCdelta). The results show that the SH3 domain of c-Abl interacts directly with PKCdelta. c-Abl phosphorylates and activates PKCdelta in vitro. We also show that IR treatment of cells is associated with c-Abl-dependent phosphorylation of PKCdelta and translocation of PKCdelta to the nucleus. These findings support a functional interaction between c-Abl and PKCdelta in the cellular response to genotoxic stress.
DOI 10.1038/sj.onc.1201698
PMID 9582011