ウツギサワ タイジユ   UTSUGISAWA Taiju
  槍澤 大樹
   所属   医学部 医学科(東京女子医科大学病院)
   職種   講師
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Activation of protein kinase C delta by the c-Abl tyrosine kinase in response to ionizing radiation.
掲載誌名 正式名:Oncogene
略  称:Oncogene
ISSNコード:09509232/09509232
掲載区分国外
巻・号・頁 16(13),pp.1643-1648
著者・共著者 Yuan Z M, Utsugisawa T, Ishiko T, Nakada S, Huang Y, Kharbanda S, Weichselbaum R, Kufe D
担当区分 2nd著者
発行年月 1998/04
概要 The c-Abl protein tyrosine kinase is activated by ionizing radiation (IR) and certain other DNA-damaging agents. The present studies demonstrate that c-Abl associates constitutively with protein kinase C delta (PKCdelta). The results show that the SH3 domain of c-Abl interacts directly with PKCdelta. c-Abl phosphorylates and activates PKCdelta in vitro. We also show that IR treatment of cells is associated with c-Abl-dependent phosphorylation of PKCdelta and translocation of PKCdelta to the nucleus. These findings support a functional interaction between c-Abl and PKCdelta in the cellular response to genotoxic stress.
DOI 10.1038/sj.onc.1201698
PMID 9582011