UTSUGISAWA Taiju
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Associate Professor |
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Article types | Original article |
Language | English |
Peer review | Peer reviewed |
Title | Pro-apoptotic effect of the c-Abl tyrosine kinase in the cellular response to 1-beta-D-arabinofuranosylcytosine. |
Journal | Formal name:Oncogene Abbreviation:Oncogene ISSN code:09509232/09509232 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 15(16),pp.1947-1952 |
Author and coauthor | Huang Y, Yuan Z M, Ishiko T, Nakada S, Utsugisawa T, Kato T, Kharbanda S, Kufe D W |
Publication date | 1997/10 |
Summary | Treatment of cells with the antimetabolite 1-beta-D-arabinofuranosylcytosine (ara-C) and other genotoxic agents is associated with activation of the c-Abl protein tyrosine kinase. The functional role of c-Abl in the response to DNA damage, however, remains unclear. The present studies demonstrate that cells expressing a dominant negative, kinase-inactive c-Abl (K-R) are resistant to killing by ara-C. The expression of c-Abl (K-R) blocked ara-C-induced apoptosis by a mechanism that is at least in part independent of the p53 tumor suppressor. Cells null for c-Abl also exhibited resistance to induction of apoptosis. These findings provide support for a pro-apoptotic function of c-Abl in the response to certain genotoxic drugs. |
DOI | 10.1038/sj.onc.1201376 |
PMID | 9365241 |