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UTSUGISAWA Taiju
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Associate Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Inhibition of phosphatidylinositol 3-kinase by c-Abl in the genotoxic stress response. |
| Journal | Formal name：The Journal of biological chemistry Abbreviation：J Biol Chem ISSN code：00219258/00219258 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 272(38),pp.23485-23488 |
| Author and coauthor | Yuan Z M, Utsugisawa T, Huang Y, Ishiko T, Nakada S, Kharbanda S, Weichselbaum R, Kufe D |
| Authorship | 2nd author |
| Publication date | 1997/09 |
| Summary | Activation of phosphatidylinositol (PI) 3-kinase by growth factors results in phosphorylation of phosphatidylinositol lipids at the D3 position. Although PI 3-kinase is essential to cell survival, little is known about mechanisms that negatively regulate this activity. Here we show that the c-Abl tyrosine kinase interacts directly with the p85 subunit of PI 3-kinase. Activation of c-Abl by ionizing radiation exposure is associated with c-Abl-dependent phosphorylation of PI 3-kinase. We also show that phosphorylation of p85 by c-Abl inhibits PI 3-kinase activity in vitro and in irradiated cells. These findings indicate that c-Abl negatively regulates PI 3-kinase in the stress response to DNA damage. |
| DOI | 10.1074/jbc.272.38.23485 |
| PMID | 9295282 |