Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Assistant Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Inhibition of phosphatidylinositol 3-kinase by c-Abl in the genotoxic stress response.
Journal Formal name:The Journal of biological chemistry
Abbreviation:J Biol Chem
ISSN code:00219258/00219258
Domestic / ForeginForegin
Volume, Issue, Page 272(38),pp.23485-23488
Author and coauthor Yuan Z M, Utsugisawa T, Huang Y, Ishiko T, Nakada S, Kharbanda S, Weichselbaum R, Kufe D
Authorship 2nd author
Publication date 1997/09
Summary Activation of phosphatidylinositol (PI) 3-kinase by growth factors results in phosphorylation of phosphatidylinositol lipids at the D3 position. Although PI 3-kinase is essential to cell survival, little is known about mechanisms that negatively regulate this activity. Here we show that the c-Abl tyrosine kinase interacts directly with the p85 subunit of PI 3-kinase. Activation of c-Abl by ionizing radiation exposure is associated with c-Abl-dependent phosphorylation of PI 3-kinase. We also show that phosphorylation of p85 by c-Abl inhibits PI 3-kinase activity in vitro and in irradiated cells. These findings indicate that c-Abl negatively regulates PI 3-kinase in the stress response to DNA damage.
DOI 10.1074/jbc.272.38.23485
PMID 9295282