ウツギサワ タイジユ   UTSUGISAWA Taiju
  槍澤 大樹
   所属   医学部 医学科(東京女子医科大学病院)
   職種   講師
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Inhibition of phosphatidylinositol 3-kinase by c-Abl in the genotoxic stress response.
掲載誌名 正式名:The Journal of biological chemistry
略  称:J Biol Chem
ISSNコード:00219258/00219258
掲載区分国外
巻・号・頁 272(38),pp.23485-23488
著者・共著者 Yuan Z M, Utsugisawa T, Huang Y, Ishiko T, Nakada S, Kharbanda S, Weichselbaum R, Kufe D
担当区分 2nd著者
発行年月 1997/09
概要 Activation of phosphatidylinositol (PI) 3-kinase by growth factors results in phosphorylation of phosphatidylinositol lipids at the D3 position. Although PI 3-kinase is essential to cell survival, little is known about mechanisms that negatively regulate this activity. Here we show that the c-Abl tyrosine kinase interacts directly with the p85 subunit of PI 3-kinase. Activation of c-Abl by ionizing radiation exposure is associated with c-Abl-dependent phosphorylation of PI 3-kinase. We also show that phosphorylation of p85 by c-Abl inhibits PI 3-kinase activity in vitro and in irradiated cells. These findings indicate that c-Abl negatively regulates PI 3-kinase in the stress response to DNA damage.
DOI 10.1074/jbc.272.38.23485
PMID 9295282