UTSUGISAWA Taiju    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Associate Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Role for E2F in DNA damage-induced entry of cells into S phase.
Journal	Formal name：Cancer research Abbreviation：Cancer Res ISSN code：00085472/00085472
Domestic / Foregin	Foregin
Volume, Issue, Page	57(17),pp.3640-3643
Author and coauthor	Huang Y, Ishiko T, Nakada S, Utsugisawa T, Kato T, Yuan Z M
Publication date	1997/09
Summary	Mammalian cells respond to ionizing radiation (IR) with transient cell cycle arrest and induction of apoptosis. Here we show that IR increases the expression of the E2F-1 transcription factor and the entry of cells into S phase. E2F-1 transactivation function is inhibited by cyclin A-kinase to ensure orderly progression through S phase. However, in contrast to proliferating cells, IR treatment results in down-regulation of cyclin A-kinase. Expression of a dominant negative form of the E2F heterodimeric partner DP-1 confirmed the involvement of E2F in IR-induced S-phase entry. These findings also support opposing signals involving the induction of E2F and the down-regulation of cyclin A-kinase in the IR response.
PMID	9288762