Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Assistant Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Role for E2F in DNA damage-induced entry of cells into S phase.
Journal Formal name:Cancer research
Abbreviation:Cancer Res
ISSN code:00085472/00085472
Domestic / ForeginForegin
Volume, Issue, Page 57(17),pp.3640-3643
Author and coauthor Huang Y, Ishiko T, Nakada S, Utsugisawa T, Kato T, Yuan Z M
Publication date 1997/09
Summary Mammalian cells respond to ionizing radiation (IR) with transient cell cycle arrest and induction of apoptosis. Here we show that IR increases the expression of the E2F-1 transcription factor and the entry of cells into S phase. E2F-1 transactivation function is inhibited by cyclin A-kinase to ensure orderly progression through S phase. However, in contrast to proliferating cells, IR treatment results in down-regulation of cyclin A-kinase. Expression of a dominant negative form of the E2F heterodimeric partner DP-1 confirmed the involvement of E2F in IR-induced S-phase entry. These findings also support opposing signals involving the induction of E2F and the down-regulation of cyclin A-kinase in the IR response.
PMID 9288762