ウツギサワ タイジユ   UTSUGISAWA Taiju
  槍澤 大樹
   所属   医学部 医学科(東京女子医科大学病院)
   職種   講師
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Role for E2F in DNA damage-induced entry of cells into S phase.
掲載誌名 正式名:Cancer research
略  称:Cancer Res
ISSNコード:00085472/00085472
掲載区分国外
巻・号・頁 57(17),pp.3640-3643
著者・共著者 Huang Y, Ishiko T, Nakada S, Utsugisawa T, Kato T, Yuan Z M
発行年月 1997/09
概要 Mammalian cells respond to ionizing radiation (IR) with transient cell cycle arrest and induction of apoptosis. Here we show that IR increases the expression of the E2F-1 transcription factor and the entry of cells into S phase. E2F-1 transactivation function is inhibited by cyclin A-kinase to ensure orderly progression through S phase. However, in contrast to proliferating cells, IR treatment results in down-regulation of cyclin A-kinase. Expression of a dominant negative form of the E2F heterodimeric partner DP-1 confirmed the involvement of E2F in IR-induced S-phase entry. These findings also support opposing signals involving the induction of E2F and the down-regulation of cyclin A-kinase in the IR response.
PMID 9288762