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コンドウ ツネノリ
KONDO Tsunenori
近藤 恒徳 所属 医学部 医学科（附属足立医療センター） 職種 教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Perinephric invasion as a prognostic factor in non-metastatic renal cell carcinoma: analysis of a nation-wide registry program. |
| 掲載誌名 | 正式名：Japanese journal of clinical oncology 略 称：Jpn J Clin Oncol ISSNコード：14653621/03682811 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 49(8),pp.772-779 |
| 著者・共著者 | Kume Haruki, Homma Yukio, Shinohara Nobuo, Obara Wataru, Kondo Tsunenori, Kimura Go, Fujimoto Hiroyuki, Nonomura Norio, Hongo Fumiya, Sugiyama Takayuki, Takahashi Masayuki, Kanayama Hiro-Omi, Fukumori Tomoharu, Eto Masatoshi |
| 発行年月 | 2019/08 |
| 概要 | OBJECTIVES:Perinephric fat invasion (PFI) of renal cell carcinoma (RCC) is known to be associated with adverse pathological features and poor prognosis. We analyzed these associations using a sub-group of the RCC registry of The Cancer Registration Committee of the Japanese Urological Association.METHODS:The study cohort of 2998 non-metastatic cases was retrieved from RCC registry (3648 in total). We compared clinicopathological characteristics of cases with PFI (n = 256) and without PFI (n = 2742), and investigated the impact of PFI on cancer-specific survival using univariate and multivariate analyses.RESULTS:Compared with non-PFI cases, PFI cases were older (P = 0.003), and more likely to be hypertensive (P = 0.034) and symptomatic at presentation (P < 0.001). PFI tumors were larger (P < 0.001), and more often have sarcomatoid component (P < 0.001) and tumor thrombus (P < 0.001). Cancer-specific survival was significantly shorter in cases with PFI than without (P < 0.001). The difference in survival tended to be greater in cases with large tumors but was significant in small tumor sub-groups. Cancer-specific survival was significantly shorter in cases with both PFI and renal vein involvement (RVI) in comparison to those with PFI or RVI alone (P = 0.011, P = 0.007, respectively). On multivariate analysis PFI with and without sinus fat invasion remained as an independent risk factor along with symptom at presentation, low body mass index, hypertension, multiple tumors, large tumor size (>7.0 cm), sarcomatoid component and RVI.CONCLUSIONS:PFI was associated with advanced age and aggressive pathological features. PFI is an independent prognostic factor in non-metastatic RCC. |
| DOI | 10.1093/jjco/hyz054 |
| PMID | 30977820 |