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チエルノフ ミハイル
チエルノフ ミハイル 所属 医学部 医学科（附属足立医療センター） 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Differentiation of the radiation-induced necrosis and tumor recurrence after gamma knife radiosurgery for brain metastases: importance of multi-voxel proton MRS |
| 掲載誌名 | 正式名：Minim Invasive Neurosurg ISSNコード：09467211 |
| 掲載区分 | 国外 |
| 出版社 | © Georg Thieme Verlag Stuttgart · New York |
| 巻・号・頁 | 48(4),pp.228-234 |
| 著者・共著者 | CHERNOV Mikhail, HAYASHI Motohiro, IZAWA Masahiro, OCHIAI Taku, YSUKURA Masao, ABE Kayoko, ONO Yuko, MURAGAKI Yoshihiro†, KUBO Osami, HORI Tomokatsu, TAKAKURA Kintomo |
| 担当区分 | 筆頭著者 |
| 発行年月 | 2005/08 |
| 概要 | Comparative analysis of the diagnostic accuracy of FDG PET, single-voxel, and multi-voxel proton MRS for differentiation between radiation-induced necrosis and tumor recurrence was done in 9 patients with brain metastases treated by gamma knife radiosurgery. In all cases enlargement of the lesion and increase of the perilesional edema were demonstrated by MRI on average 10.6+/-2.6 months after initial treatment. Radiation-induced necrosis was identified in 5 patients (histologically in 2, clinically in 3). In one of these a false positive result of FDG PET was observed, whereas data of proton MRS were always correct. The diagnosis of tumor recurrence was established in 4 patients (histologically in 3, clinically in 1). Among these both FDG PET and single-voxel proton MRS showed false negative results (each method twice), whereas multi-voxel proton MRS always permitted us to establish the correct diagnosis. The present study demonstrates the higher diagnostic accuracy of multi-voxel proton MRS, in comparison with single-voxel proton MRS and FDG PET, for the differentiation of the radiation-induced necrosis and tumor recurrence. Its use is especially important in mixed lesions with co-existence of both post-irradiation changes and viable neoplasm. Monitoring of the treatment response by serial multi-voxel proton MRS seems to be reasonable during follow-up of patients with brain metastases after radiosurgery. |
| DOI | 10.1055/s-2005-870952 |
| 文献番号 | 16172969 |
| PMID | 16172969 |