チエルノフ　ミハイル
   Department   School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine
   Position   Assistant Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Metabolic characteristics of intracranial metastases, detected by single-voxel proton magnetic resonance spectroscopy, are seemingly not predictive for tumor response to gamma knife radiosurgery
Journal Formal name：Minim Invasive Neurosurg
ISSN code：09467211
Domestic / ForeginForegin
Publisher Georg Thieme Verlag KG Stuttgart · New York
Volume, Issue, Page 50(4),pp.233-238
Author and coauthor CHERNOV Mikhail†, HAYASHI Motohiro, IZAWA Masahiro, NAKAYA Kotaro, ONO Yuko, USUKURA Masao, YOSHIDA Shigetoshi, KATO Koichi, MURAGAKI Yoshihiro, NAKAMURA Ryoichi, ISEKI Hiroshi, HORI Tomokatsu, TAKAKURA Kintomo
Authorship Lead author
Publication date 2007
Summary Metabolic characteristics of intracranial metastases, detected with proton magnetic resonance spectroscopy (1H-MRS) have known associations with clinical predictors of tumor response to radiosurgery. Therefore, it can be suspected that the metabolic profile of the neoplasm by itself might have some prognostic significance for the outcome after irradiation. Twenty-six intracranial metastases, which underwent metabolic evaluation with single-voxel 1H-MRS before gamma knife radiosurgery (GKR) and were followed for at least 3 months after treatment, were selected for retrospective analysis. The tumors most frequently originated from the lungs (9 cases), breast (7 cases), colon and rectum (5 cases). The average volume of the investigated intracranial neoplasm was 5.4+/-2.0 mL. The average marginal irradiation dose was 18.6+/-2.3 Gy. The mean follow-up after GKR constituted 8.0+/-5.5 months. Tumor response to GKR was identified in 13 cases on average 2.2+/-1.8 months after treatment. Local recurrence was marked in 10 cases on average 8.7+/-4.1 months after treatment. None of the investigated 1H-MRS metabolic parameters of intracranial metastases showed a statistically significant association with the outcome after GKR. The negative results of the present study make doubtful the predictive value of metabolic characteristics of intracranial metastases, detected with single-voxel 1H-MRS, for the outcome after radiosurgery.
DOI 10.1055/s-2007-985891
Document No. 17948183